Spotlight on faecal incontinence in the Journal of Cell and Gene Therapy Insights


2 January 2024

We are proud of our team’s contribution to the Cell & Gene Therapy Insights article. Thanks to Martha Gilbert, Simona Čaputová, Delielena Poli, Manou Kooy for the valuable insights!

About the article

The latest edition of the Journal of Cell and Gene Therapy Insights sheds light on the causes and consequences of fecal incontinence. Sphincter injury stands out as a leading cause, and this article delves into the potential of innovative technologies like cell therapy to revolutionize treatment options for this overlooked patient population.

Faecal incontinence is a prevalent condition, that remains vastly underreported. The condition impacts the patients’ quality of life and has negative socio-economic and environmental impact on the society. Current patient management guidelines recommend a stepwise approach to treating faecal incontinence, from conservative treatment options, through minimally invasive surgical options, all the way to first- and second-line surgical options. Unfortunately, the conservative treatments remain ineffective, and, in many cases, the surgical options are either not desirable or not suitable. Regenerative medicine, and specifically, cell therapy, has the potential to offer a curative treatment that is less invasive, more effective and efficient. Cell therapy technologies, while still under development, can improve the current state-of-play in the realm of faecal incontinence at the clinical, patient, and socio-economic level. The aim of this article is twofold. Firstly, it is to raise awareness about the silent affliction that faecal incontinence is and about the impact that it has on patients and society. Secondly, it is to position cell therapy, relative to the current treatment approaches, including, for example, sacral nerve stimulation and sphincteroplasty, as to emphasise its potential to provide a suitable treatment alternative.

You can find an extract of the article here


The problem: Fecal incontinence is a prevalent condition that is currently lacking appropriate treatment options. While underreported, FI is a prevalent condition, most common in parous women, frail older patients and patients with neurological disorders. Current treatment options for treating FI are often either not effective, or not desirable and/or suitable. FI impacts patients’ quality of life and has socio-economic and environmental implications on the society

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